Double Blind Clinical Trial conducted by the Western University School of Health Sciences College of Podiatric Medicine on subjects with dry, cracked heels.
Researchers at Western University of Health Sciences College of Podiatric Medicine compared SkinIntegra with high-strength Urea-40 in a randomized, double-blind trial of 48 adults with dry, cracked heels. Podiatrists assessed every patient, and the results were published in a peer-reviewed journal. The percentages below come from the SkinIntegra group's own trial data.
Patients using SkinIntegra improved in dryness and cracking within 2 weeks, with no new or worsening irritation.
With continued twice-daily use, more patients saw improvement. By 4 weeks, 82% of patients had less dry skin and 73% saw an improvement in cracked skin, measured against each patient's own starting point.
Both creams improved dryness and cracking comparably at 2 and 4 weeks, with 25% urea in SkinIntegra versus 40% in Urea-40. No SkinIntegra patient had an increase in redness, burning, stinging or itching; investigators separately noted irritation with extended Urea-40 use. Overall tolerability scores were comparable between groups.
Source: Ross AJ, Pereira J, Moellmer R, Hubbard C, Deogracias RT, Zahid F. Comparative efficacy of novel skin barrier repair cream and urea 40% for the management of pedal fissures. J Am Podiatr Med Assoc. 2025;115(5). doi:10.7547/24-062. Funded by a SkinIntegra grant. SkinIntegra had no role in the design or conduct of the study; the collection, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript. Limitations: small sample (48 completers of 60 enrolled); 7 participants used one cream on each foot. Within-group percentages are from the SkinIntegra group (n=22) and are not a between-group comparison.
